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Original Contribution
November 16, 1964

Leukemia in ChildrenIncidence, Clinical Manifestations, and Survival in an Unselected Series

JAMA. 1964;190(7):578-582. doi:10.1001/jama.1964.03070200014003

Information was collected about each child who died from leukemia in Oregon during the period 1950 to 1961. The annual incidence was 4.53 per 100,000. A peak of incidence occurred at three years. When the series was divided into two time periods (1950 to 1955, and 1956 to 1961), survival was found to be longer in the more recent group and suggests improved management of the disease in recent years. While the survival data in this study represent the fate of the leukemic child in contemporary America, they compare unfavorably with experience reported from medical centers. Two explanations are advanced for this: either treatment is more efficient in medical centers, or center experience is so selected that findings derived from it cannot safely be generalized.