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November 16, 1964

Tetracycline Toxicity in Pregnancy

JAMA. 1964;190(7):689. doi:10.1001/jama.1964.03070200125035

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To the Editor:—  In regard to the paper by Whalley et al entitled "Tetracycline Toxicity in Pregnancy: Liver and Pancreatic Dysfunction" (JAMA189:357 [Aug 3] 1964), I wonder if the authors performed retrograde pyelograms or excretory urograms on the patients later in their courses. No mention of such studies is made; they were either not described because of space considerations or else not performed. If they were not done it is possible that serious obstructive diseases of the urinary tract or other lesions of the kidney could have been overlooked. The basic tenets of the paper would still not be abrogated. However, in some instances acute renal failure is associated with liver failure by an unknown mechanism and could be involved in some cases. In fact, in the same issue of The Journal (References and Reviews, adv p 149), there is an abstract of a paper from the Annals

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