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December 28, 1964


JAMA. 1964;190(13):1125. doi:10.1001/jama.1964.03070260037013

Endarteritis obliterans has been considered an obliterating, proliferative thickening of the intima due either to a diminished functional demand or to irritants diffusing from a chronic inflammatory lesion nearby. Diffusing irritants have been invoked as the prime etiological factor in the pathogenesis of endarteritis obliterans in the vicinity of chronic peptic ulcers, but current textbooks of pathology provide inadequate and conflicting descriptions of these vascular changes.

A description of the histological features of blood vessels near chronic peptic ulcers, and a comparison with vessels at some distance from the ulcer, appears in the December issue of the Archives of Pathology.1 Arterial changes in the vicinity of the ulcers appear to be localized accentuations of either arteriosclerosis or diffuse hyperplastic sclerosis, which normally occur in gastric, intrarenal, and other visceral arteries. Striking similarities to atherosclerosis, diffuse hyperplastic sclerosis (arteriosclerosis), and arteriolosclerosis are noted. The predominant features described are not those

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