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January 5, 1963

Methylcellulose-Induced Regression of Murphy-Sturm Lymphosarcoma in the Rat

Author Affiliations


From The Department of Pathology, University of Chicago Hospitals.; Dr. Lazar's present address is American Registry of Pathology, Armed Forces Institute of Pathology, Washington 25, D.C.

JAMA. 1963;183(1):33-35. doi:10.1001/jama.1963.63700010006014b

METHYLCELLULOSE (MC) is a long-chain polymer, a methyl ether of cellulose which forms a colloidal suspension. It is not absorbed from the alimentary tract. After intraperitoneal or intravascular injection of amounts comparable to those used in this study, the following changes are among those which have been observed: hypersplenism and hemolytic anemia1; a nephrotic-like syndrome due to renal damage induced by MC2; increase in circulating gamma globulin due to the appearance of a new gamma globulin fraction1; decrease in hemolysin formation1; and storage of large amounts of MC in endothelial cells of glomeruli and macrophages, especially in the spleen and liver.

Materials and Methods  Nonlittermate male Sprague-Dawley rats weighing from 300 to 360 gm were divided into groups which averaged 340- to 350-gm. All animals were on laboratory rat chow diet and water ad libitum throughout the studies.The subcutaneous transplantation of the lymphosarcoma and