SELECTIVE UPTAKE of radioactive phosphorus (P3~) by malignant tumors has been well documented since the early 1940's. During the past 20 years, various groups of investigators have devised techniques for diagnosis of tumors in many areas of the body by measuring P32 uptake. In these studies, radioactivity was measured by counting over the suspicious area with a Geiger-Müller tube and comparing the level of activity with counts obtained over normal areas. This technique has been used in studying cancers of the stomach and esophagus, skin, breast, eye, brain, head and neck, thyroid, cervix, testis, bladder, and lung.1-4
The use of in vivo diagnostic radioautography has several potential advantages over standard counting methods. Radioautography is a more sensitive technique for detecting small differences in radioactivity. It is able to detect small foci of P32 activity in tumors with necrotic or fibrous elements. Radioautographs must remain in
Ackerman NB, McFee AS, Blum JA, Makowski EL, Wangensteen OH. Multiple-Organ Cancer Screening with Diagnostic Radioautographic Procedures. JAMA. 1963;183(1):36–39. doi:10.1001/jama.1963.63700010009014c
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