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January 5, 1963

Response to Chlorambucil in Macroglobulinemia

Author Affiliations

Madison, Wis.

From the Department of Medicine, University of Wisconsin Medical School.

JAMA. 1963;183(1):40-44. doi:10.1001/jama.1963.63700010013014d

MACROGLOBULINEMIA has been the subject of many reports and of several recent reviews.1-3 Waldenström4 first noted the occurrence of high molecular weight serum globulins as a prominent feature of certain blood dyscrasias. Despite the possibility of multiple etiologic factors, the well-defined biochemical abnormality and a generally recognized clinical picture lead one to the acceptance of macroglobulinemia as a disease entity. The disease is now considered to be a neoplasm of the reticuloendothelial system characterized by the proliferation of an abnormal cell type from which the macroglobulins probably originate. The abnormal cell has been variously described as "lymphocytoid," "lymphoid," and "plasmacytoid." It is our prime intention to report the results obtained with long-term administration of chlorambucil to our 2 patients with this condition, supporting the favorable observations reported by Bayrd.5

Material and Methods  We have had the opportunity to follow the clinical courses and serum protein patterns