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January 5, 1963

Renal and Ureteral Damage Following Clinical Use of Renacidin

Author Affiliations

Dearborn, Mich.

Resident in Pathology, Wayne State University, Detroit (Dr. Auerbach), Director of Laboratories (Dr. Mainwaring), and Staff Urologist (Dr. Schwarz), Oakwood Hospital, Dearborn, Mich.

JAMA. 1963;183(1):61-63. doi:10.1001/jama.1963.63700010030020a

A NUMBER OF REPORTS have appeared in the recent literature describing the clinical use of Renacidin in the treatment of urinary calculi.1-6 Renacidin is described as a readily soluble white powder composed of a sterile mixture of the anhydrides, lactones, and acid salts of a group of multivalent food acids in a stabilizer.5 The use of Renacidin as a solvent for urinary calculi has been investigated by a number of workers, most of whom report encouraging results. There have been, however, occasional toxic reactions. The complications which have been reported include obstruction of the irrigating catheter by debris, pain associated with plugging of the catheter, febrile reactions and, in one case, sloughing and necrosis of the renal epithelium.4

This is a report of a patient with severe pyelonephritis, ureteritis, and chemical pyelitis, who was treated with Renacidin in an attempt to dissolve a renal calculus.

Report of