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January 5, 1963

Detecting Small Sessile Colon Cancers with Silicone Foam

Author Affiliations

St. Louis

Assistant in Surgery (Dr. Cook) and Professor of Radiology (Dr. Margulis) and from the Department of Surgery and The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine.

JAMA. 1963;183(1):66-68. doi:10.1001/jama.1963.63700010035020c

THE MORE FAVORABLE RESULTS associated with early treatment of cancer foster continued effort to increase the accuracy and sensitivity of diagnostic methods. This motivation has led to modifying and improving radiologic and endoscopic techniques and to developing more precise means for collecting and studying exfoliative specimens of the colon.

To this end we are attempting to improve the detection of tumors within the human sigmoid colon by evaluating a diagnostic enema that can be retrieved as a precise mold of the bowel to permit the recognition of small mucosal irregularities and the recovery of adherent cells.

Method and Subjects  The 125-ml enema is a nontoxic, liquid prepolymer of dimethylpolysiloxanes made radiopaque with barium sulfate or sodium diatrizoate. Polymerized by 2 ml of stannous octoate, the siliconeelastomer changes endothermically to a soft, elastic foam that molds the viscus containing it. The formulation and the techniques for administering the enema have been