A study was carried out on a group of men under the age of 50 who had suffered myocardial infarction and who were receiving estrogens. The primary purpose was to determine whether long-term estrogen therapy with associated feminization would adversely affect the psyche of these men, hence outweighing the physiological benefits of the drug. The findings indicate that long-term estrogen therapy was tolerated in most patients with regard to the emotional aspects. The stress of the coronary disease was greater than the stress of feminization. There were no significant psychiatric or emotional disturbances attributed to estrogens. The gravity of the coronary disease, role of group psychotherapy, and special interest evinced by the cardiologists were the important motivating factors in the patients who remained throughout the study.
Benjamin M. Kaplan, Jerome Grunes. Emotional Aspects of Estrogen Therapy in Men with Coronary Atherosclerosis. JAMA. 1963;183(9):734–736. doi:10.1001/jama.1963.03700090054008