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March 2, 1963

Aldosteronism in Man: Some Clinical and Climatological Aspects Part I

Author Affiliations

Ann Arbor, Mich.

From the Department of Internal Medicine, The University of Michigan Medical Center. Professor of Internal Medicine and Director of the Division of Endocrinology and Metabolism and the Metabolism Research Unit.

JAMA. 1963;183(9):775-781. doi:10.1001/jama.1963.63700090021015

OUR INTEREST in aldosterone goes back many years before the hormone was actually discovered. During those years were referred to it as a "desoxycorticosterone-like steroid" produced by the adrenal cortex.1-6 I have chosen, therefore, to review first some of our older work dealing with the mechanisms by which men adapt to work in the heat, and then to make some comments about things we have learned about primary aldosteronism during the past few years. Although these two areas appear to be related only casually, to me they are very intimately related, for our thinking had been so conditioned by the work on acclimatization that it led us to interpret as primary aldosteronism7,8 a fascinating combination of circumstances.

Some Aspects of the Physiology of Acclimatization to Heat  In the light of recent advances in knowledge of the physiology of aldosterone secretion, as well as of the activities of