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March 9, 1963

A Study of the Late Effects of Total Body Irradiation

JAMA. 1963;183(10):859-860. doi:10.1001/jama.1963.63700100011013c

THE INTRAVENOUS ADMINISTRATION of autologous marrow will prevent death following irradiation exposure which would be lethal in untreated animals.1,2 The early effects of marrow transplants are well documented, but there is little information concerning the physiologic status in the late postirradiation period of large animals so treated. We have utilized fresh marrow, frozen marrow, and spleen as autologous transplants in the dog with success. The present report consists of physiologic studies in dogs surviving large doses of total body irradiation.

Materials and Methods  Mongrel dogs were irradiated with a 2 mv Van de Graaff x-ray generator. The half-value layer of the x-ray beam was 8 mm lead. The exposure dose was measured at the treating distance of 217 cm. Half of the exposure was delivered to the left side of the animal and half to the right. The dose rate was 15 to 17 roentgens/min so that treatment

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