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March 9, 1963

New Drugs and Developments in TherapeuticsCouncil on Drugs' Statements

JAMA. 1963;183(10):880-881. doi:10.1001/jama.1963.63700100032016

Mepivacaine Hydrochloride (Carbocaine Hydrochloride) 

Summary of Council Opinion.—  Mepivacaine hydrochloride (d,l-N-methylpipecolic acid 2,6-dimethylanilide hydrochloride) is a useful and potent local anesthetic agent essentially similar in action to lidocaine. It is a relatively nontoxic, nontissue-irritating drug having a longer duration of action than previously available agents in this group. This action is obtained without the addition of epinephrine or other vasoconstrictor agents and presents an obvious advantage in cases in which vasoconstriction is undesirable. At the present time there is insufficient evidence to substantiate its efficacy or safety when used either intrathecally or topically.

Actions and Uses.—  Mepivacaine hydrochloride is a potent local anesthetic agent essentially similar in action to lidocaine, both drugs being approximately twice as potent as procaine. However, the duration of effect of mepivacaine is appreciably longer than that of lidocaine, and epinephrine may not have to be added when this agent is used. This gives

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