[Skip to Content]
[Skip to Content Landing]
Other Articles
February 23, 1963


JAMA. 1963;183(8):682. doi:10.1001/jama.1963.03700080090019

In this issue a report (p 632) is presented on the effects of estrogens in men under 50 years of age who have had a myocardial infarction. The estrogens employed were in the form of the natural hormones, mixed conjugated equine estrogens (Premarin). The sole criterion used to evaluate their beneficial effect was the five-year rate of survival of men so treated as compared with a matched group given a placebo. It was found that a statistically significant augmentation of survival rate (approximately 50% at the end of five years of therapy) was obtained with the estrogen preparation when administered over a long-term period in a dosage of 10 mg per day orally. This was accompanied by an alteration in the blood lipoprotein-lipid pattern. The large dosage led to breast enlargement and loss of libido and potency. No other significant unwanted effects were noted when estrogen therapy was begun three

First Page Preview View Large
First page PDF preview
First page PDF preview