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To the Editor:—
Several studies have reported that the antibody response following the intradermal injection of one-tenth the routine subcutaneous dose of influenza vaccine was comparable to the antibody response induced by the administration of the routine full dosage of vaccine subcutaneously. However, since different volumes of vaccine were inoculated, it remained uncertain whether the comparable antibody responses were actually related to the route of administration.McCarroll and Kilbourne (New Engl J Med259:618-621,1958) compared the antibody responses of adults to equal volumes of Asian influenza vaccine administered by either the subcutaneous or intradermal routes. They found that when equal small volumes of vaccine were administered either subcutaneously or intradermally at similar intervals, the subcutaneous route was at least equivalent to the intradermal route in its ability to induce the formation of homologous antibody. Klein and Huang (J Pediat58:312-314, 1961) compared the responses of infants and children
Pine I, Kapikian AZ. Influenza Vaccination-Reply. JAMA. 1962;180(3):263. doi:10.1001/jama.1962.03050160079030
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