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April 28, 1962

Steroids in Nephrotic Syndrome

JAMA. 1962;180(4):346. doi:10.1001/jama.1962.03050170078020

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To the Editor:—  I have just read Heymann's and Hunter's article "Importance of Early Treatment of the Nephrotic Syndrome (JAMA175:563 [Feb. 18] 1961). I should like to comment on the article.Recovery from the nephrotic syndrome in children is more likely to take place when the disease has lasted for a short time. When the nephrotic syndrome has persisted for a long time there is little probability of recovery. As far as I can see, the authors have missed this important point. They have found a statistically significant difference in prognosis between the group of children starting steroid treatment within the first 3 months after onset of the disease and the group starting treatment any time thereafter. I am not surprised that they find a statistically significant difference between these 2 groups but I am surprised that the authors claim it to be the result of early steroid

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