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April 28, 1962

The Action of Insulin on Cells

JAMA. 1962;180(4):349-350. doi:10.1001/jama.1962.03050170081029

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The author has set as his task to review, "in current chemical terms, the effects of insulin upon carbohydrate, fat and nitrogen metabolism in the principal insulin-responsive tissues. After the individual effects have been identified, an attempt is made to devise a mechanism of action which will account for these separate effects." In this task, the author has reviewed the subject very well. He has not merely compiled isolated experiments, but has attempted, and generally succeeded in, intelligent interpretation of the results. His speculations on the possible fundamental action of insulin, in contrast to its observable effects, are interesting. Others have presented different hypotheses, and again others similar ones; while unproved, these speculations are useful in guiding future research.

The first portion of the book is concerned with the effects of insulin on specific tissues, e.g., muscle, liver, adipose, and so forth. Next, the influence of insulin on permeability of

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