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Since the first edition was published in 1942, it has undergone revision every 4 or 5 years. Unlike many volumes of similar proportions, the immense task of keeping pace with the rapid advance of knowledge in both basic and clinical areas falls solely to the original author and not to a panel of experts. To see the presentation as well done in this fifth edition as in the previous 4 is to understand what has made this book a classic in its field and has assured its evergrowing popularity.
The organization of the book has not changed appreciably. The content, however, differs from that of the 1956 edition. Thus the section on the biochemistry of the erythrocyte has been greatly expanded, and the red cell enzymatic defect responsible for favism and primaquine sensitivity carefully detailed. The hemoglobinopathies are dealt with at molecular level, in keeping with the rapid growth of
Jacobson LO. Clinical Hematology. JAMA. 1962;180(4):350. doi:10.1001/jama.1962.03050170082030
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