Travelers to all lands have suffered attacks of diarrhea. A double-blind study tested the efficacy of 2 antimicrobial drugs in the prevention of tourist diarrhea among 473 American college students in Mexico City. One group of 168 received a lactose placebo, 137 received neomycin sulfate (1 gm. per day), and 168 received phthalylsulfathiazole (2 gm. per day), all under close supervision. Moderate or severe diarrhea occured in 17% (29) of those who took the placebo, 5% (7) of those who took neomycin, and 7% (11) of those who took phthalylsulfathiazole. Among these initially healthy and carefully supervised young persons no untoward reactions were observed, but if these drugs are to he used as prophylactic agents on a larger scale, their administration should be accompanied by similar medical precautions.
Kean BH, Schaffner W, Brennan RW, Waters SR. The Diarrhea of Travelers: V. Prophylaxis with Phthalylsulfathiazole and Neomycin Sulphate. JAMA. 1962;180(5):367–371. doi:10.1001/jama.1962.03050180013004
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