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May 5, 1962

The Diarrhea of Travelers: V. Prophylaxis with Phthalylsulfathiazole and Neomycin Sulphate

Author Affiliations

New York City

From the Department of Public Health, the New York Hospital-Cornell University Medical Center (Dr. Kean).

JAMA. 1962;180(5):367-371. doi:10.1001/jama.1962.03050180013004

Travelers to all lands have suffered attacks of diarrhea. A double-blind study tested the efficacy of 2 antimicrobial drugs in the prevention of tourist diarrhea among 473 American college students in Mexico City. One group of 168 received a lactose placebo, 137 received neomycin sulfate (1 gm. per day), and 168 received phthalylsulfathiazole (2 gm. per day), all under close supervision. Moderate or severe diarrhea occured in 17% (29) of those who took the placebo, 5% (7) of those who took neomycin, and 7% (11) of those who took phthalylsulfathiazole. Among these initially healthy and carefully supervised young persons no untoward reactions were observed, but if these drugs are to he used as prophylactic agents on a larger scale, their administration should be accompanied by similar medical precautions.