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May 5, 1962

Cerebrospinal Fluid Dynamics in Health and Disease

JAMA. 1962;180(5):431. doi:10.1001/jama.1962.03050180077029

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This monograph presents the experimental investigations of 2 centuries, and the important advances of the past decade. Five chapters are devoted to the accumulated evidence on the absorption of cerebrospinal fluid, the production of cerebrospinal fluid, dynamic factors, the mechanics and treatment of hydrocephalus, and to other disorders of cerebrospinal fluid mechanics. Among the older hypotheses some stand as even more likely, whereas other notions must now be abandoned in favor of entirely fresh concepts which have emerged. This work shows how the availability of new materials and new techniques permit the overcoming of obstacles inherent in former methods of investigation. Two factors previously hampered the study of the cerebrospinal fluid system in its natural state—the alteration, through opening the system, of the hydrodynamic conditions under which it normally exists, and the great susceptibility to irritation of the meninges and blood vessels of the neuraxis caused by the introduction of

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