Sixty-four patients with suspected renal hypertension were studied with I131 sodium o-iodohippurate (Hippuran) renograms, retrograde ureteral catherization studies and arteriograms; occlusive renal vascular disease was found at operation in 20 patients. The renogram was "correct" in 9 of 9 cases with unilateral main artery occlusion, in 4 of 6 cases of bilateral occlusive disease, and in 2 of 5 cases of segmental disease. A quantitative method of interpretation was superior to qualitative evaluation. The radioisotope renogram, by the present technique, was ineffective as a "screening" test of renal hypertension since false-negative results were noted with significant frequency in patients with correctable renal ischemia. It was useful, however, as one of several tests in the evaluation of hypertensive patients and in following patients after revascularization procedures.
Stewart BH, Haynie TP. Critical Appraisal of the Renogram in Renal Vascular Diseas Renogram. JAMA. 1962;180(6):454–459. doi:10.1001/jama.1962.03050190016003
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