The T waves of the electrocardiogram are sometimes altered in the absence of heart disease, but the author has not found any reports of T wave changes occurring cyclically in association with the menstrual period. In the present case the T wave changes occurred in the intermenstrual periods. The changes suggested myocardial ischemia, but there was no associated pain, dyspnea, or other evidence of heart disease. Following a supravaginal hysterectomy and bilateral salpingoovariectomy because of a large uterine fibroid, electrocardiograms made twice weekly for 10 months and once weekly for 6 months thereafter have been normal. The time relationship suggested that the electrocardiographic changes were apparently associated with some intermenstrual process, but efforts to reproduce the T wave changes by hormone treatment were not successful.
Edeiken J. Cyclic Changes in T Waves. JAMA. 1962;180(6):460–462. doi:10.1001/jama.1962.03050190022004
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