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May 12, 1962

Treatment of "Dumping with Serotonin Antagonists: Preliminary Report

JAMA. 1962;180(6):493-494. doi:10.1001/jama.1962.03050190000014b

RECENT STUDIES in our laboratories have shown that a circulating agent of intestinal origin may be responsible for initiating the early symptomatic phase of the postgastrectomy dumping syndrome. Since serotonin and related substances have pharmacologie actions compatible with the physiologic derangements seen in dumping, and are released from the upper small intestine in response to a hyperosmolar intraluminal stimulus, we believe that serotonin or a related agent may be of etiologic importance in the syndrome. Furthermore, with certain antiserotonin drugs, it is possible to prevent the experimental "dumping" syndrome in the dog as measured by plethysmography. The present report outlines our early experience with one of these agents, cyproheptadine (Periactin), in the treatment of postgastrectomy patients with moderate to severe dumping.

Ten patients, each of whom had well-documented postgastrectomy dumping, were given 12 to 24 mg. of cyproheptadine daily, in divided oral doses, taken approximately 2 hours prior to meals.