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To the Editor:—
The contention of Drs. de Takats and Fowler (JAMA179:1, Jan. 6) that Raynaud's phenomenon often precedes the other manifestations of collagen disorders by many years is contrary to the experiences reported previously by us (Circulation16:1012, 1957). One facet of this study concerned 280 women and girls who had had Raynaud's phenomenon for at least 2 years without other manifestations of systemic disease when they were first examined at the Mayo Clinic. Follow-up study indicated that only 13 (5%) of these patients subsequently developed systemic disease to which the Raynaud's phenomenon could have been related. The mean duration of follow-up for this group was 17 years from the onset of symptoms of Raynaud's phenomenon.While we agree with Drs. de Takats and Fowler that sympathectomy usually fails when Raynaud's phenomenon is secondary to a collagen disease, our data would indicate that this can explain
Gifford RW, Hines EA. Raynaud's Phenomenon. JAMA. 1962;180(8):702–703. doi:10.1001/jama.1962.03050210064024
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