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June 2, 1962

The Nomenclature of Blood Clotting Factors

JAMA. 1962;180(9):733-735. doi:10.1001/jama.1962.03050220025007

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IN 1954 the International Committee for the Nomenclature of Blood Clotting Factors was established with one of its primary objectives the development of a common scientific terminology in this field. At that time, the situation was chaotic, with most of the factors being referred to in the literature by multiple, often totally unrelated names—14 different terms were used for one of them. The committee is composed of 23 members from 15 countries, all of whom have played significant roles in the discovery or application of knowledge regarding these factors. After 4 years of deliberations, the first report was issued which recommended that Roman numerals should be used for the designation of those factors which, in the opinion of the committee, were sufficiently defined as distinct entities by physiopathological, physical, biochemical, and chemical properties. It was also agreed that an author could, if he so desired, use a synonymous term in

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