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June 2, 1962

The Second Multiple Discipline Research Forum of the American Medical Association

JAMA. 1962;180(9):752-774. doi:10.1001/jama.1962.03050220044007e

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Tuesday, June 26—9 a.m.

McCormick Place, Room A

Presiding: J. Arnold Bargen, M.D., Temple, Tex. Member, Council on Scientific Assembly

Moderator: Michael E. De Bakey, M.D., Houston, Tex. 9:00 a.m.


Panelists: I. George Weber, M.D., Indianapolis 2. Rudolf J. Noer, M.D., Louisville, Ky. 3. George Moore, M.D., Buffalo


1. Influence of Nitrogen Mustard on Tumor Implantation

Isidore Cohn, Jr., M.D., Efraim A. Gonzales, M.D., Cecil E. Floyd, M.D.,Colin M. Freeman, M.D., and M. Atik, M.D., Department of Surgery, Louisiana State University School of Medicine, New Orleans

Experience in this laboratory with various methods of control of tumor implantation following spillage of Brown-Pearce tumor in operations on the rabbit colon made this seem an appropriate experimental tool to study the role of nitrogen mustard in controlling tumor spread.

In 38 paired experiments, the peritoneal cavity was irrigated with either saline or nitrogen mustard after the tumor was injected. Tumor

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