INCREASED SERUM ENZYMES have been found in certain neuromuscular diseases, e.g. muscular dystrophy, and glutamic oxaloacetic transaminase (GOT) values of cerebrospinal fluid (CSF) have been found to be elevated in cerebral infarction following cerebrovascular accidents, in brain damage associated with head injury, as well as in some other conditions of nervous system disease.
It has been noted that the blood-CSF barrier results in enzyme activities that are relatively independent for serum and cerebrospinal fluid. (A recent study using I131 in puppies demonstrated the increased permeability of the blood-CSF barrier to GOT after prolonged hypoxia.) For this reason and because of the relative ease of acquiring blood, the clinical study of CSF enzymes and the knowledge of their alterations have been limited.
Since this study was completed, increased CSF-GOT values have been found in children with acute paralytic poliomyelitis with no serum-glutamic oxaloacetic transaminase (S-GOT) correlation, and, an elevated S-GOT has
Steen SN, Thomas JS. Glutamic Oxaloacetic Transaminase in Serum and Cerebrospinal Fluid in Parkinsonism. JAMA. 1962;180(10):836–837. doi:10.1001/jama.1962.03050230038017
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