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June 9, 1962

Analysis of Sodium o-Iodohippurate Renogram

Author Affiliations

410 W. 10th Ave., Columbus 10, Ohio

JAMA. 1962;180(10):901. doi:10.1001/jama.1962.03050230103024

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To the Editor:—  This note is in reference to an article by Wax and McDonald, entitled "Analysis of the I131 Sodium o-Iodohippurate Renogram," that appeared in The Journal (179:140 [Jan. 13] 1962). I wish to comment on some aspects of their experimentation, offer some pertinent observations from our work, and express a disagreement with their statement that "the term 'vascular phase,' which has been used widely in applying the renogram to hyptertensive studies, is misleading and should be discarded."Their experiments, in dogs, were carried out with the ratemeter set at a 10-second time constant. This means that there was a 35-second lag in a record made by an instrument that has too good a "memory," and thereby allows a false impression to be made of what may be taking place during a period of rapid change. In the analysis of the renogram's initial segment that is completed

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