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June 16, 1962

Clinical Science

JAMA. 1962;180(11):958-964. doi:10.1001/jama.1962.03050240054011

Leukocyte and Thrombocyte Antibodies 

Current Concepts of Their Origin, Identity, and Significance  James L. Tullis, M.D., Jamaica Plain, Mass.THE CONCEPT that the antileukocyte and antithrombocyte proteins derived from leukopenic and thrombocytopenic serum may be antibodies has been slow to win acceptance. Although it has been known since the early work of Doan1 that isoimmune leukoagglutinins can induce pyrogenic and urticarial transfusion reactions and that heterologous platelet antibodies can induce experimental thrombocytopenic purpura, the translation of these observations into naturally occurring disease states has met with resistance. This in part can be traced to the lack of reliability of the many tests which have been introduced to screen for the antibodies presumed to be present in the serum of patients with idiopathic thrombocytopenic purpura (ITP). Although Oliva and Burbetta, in 1944,2 and Evans and associates, in 1951,3 showed that such serum would agglutinate platelets in vitro, and