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June 16, 1962

The Use of Aminopyrine to Control Fever in Hodgkin's Disease

Author Affiliations

Brooklyn. N.Y.

JAMA. 1962;180(11):970-972. doi:10.1001/jama.1962.03050240066018

SINCE HODGKIN'S DISEASE was first described in 1832, x-rays, alkylating agents, antimetabolites, and steroids have become available as therapeutic agents. Nevertheless, therapy of the disease continues to remain a problem, and management, particularly in the later stages after dissemination has occurred, is still unsatisfactory. Fever is one of the more bothersome symptoms with which the physician has to deal. A simple method of treating this fever is used so little that it is worth reporting in some detail.

The fever of Hodgkin's disease may be continuous, but more usually is relapsing (Pel-Ebstein fever). Its incidence is variously reported to be from 30% to 50%. When fever does occur, it is usually a cause of disability by virtue of the malaise, weakness, sweating, anorexia, and headache, which are the direct consequences of elevated body temperatures. If the disease is left to run an uninhibited febrile course, it is usual for the