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June 16, 1962

The Rhesus and MN Blood Groups and Disease-Reply

Author Affiliations

State University of Iowa, Iowa City

JAMA. 1962;180(11):988. doi:10.1001/jama.1962.03050240084025

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To the Editor:—  Mistakes in blood grouping are an unlikely explanation for the excess of MN individuals in either the control or the patient groups. All of the typings were performed at random by 1 technician, using commercial, high titer, standardized, specific, rabbit antisera. The cells are promptly agglutinated by the proper antisera, which is readily noted on inspection of the tube containing the cells and antisera. Some of the more plausible explanations for the unexpected high MN frequencies observed in this study have been suggested by Morton and Chung (Amer J Hum Genet11:237-251 [Sept.] 1959). If Dr. Wiener's contention is granted, since groupings were done at random both for controls and patients, no explanation is provided for the discrepancies between the controls and the rheumatic fever patients, and the agreement in the MN frequencies of the controls with those of duodenal and gastric ulcer, gastric carcinoma, and

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