Ten women and 6 children with adrenogenital syndrome were treated with injections of prednisolone trimethylacetate or methylprednisolone acetate at 2- to 3-week intervals for periods of as long as 22 months. Both steroids produced satisfactory adrenal suppression in most patients, but prednisolone trimethylacetate appeared to be slightly more effective than equivalent doses of methylprednisolone acetate in lowering urinary 17-ketosteroids and improving menstrual function in the adults. There was, however, no apparent difference in the therapeutic action of either steroid in the children. The advantage of intermittent parenteral therapy over daily oral therapy in some patients is briefly discussed.
Dingman JF, Maranan LC, Staub MC. Treatment of Adrenogenital Syndrome: Intramuscular Therapy with Long-Acting Prednisteroids. JAMA. 1962;180(12):1017–1020. doi:10.1001/jama.1962.03050250023005
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