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June 23, 1962

Clinical Science

JAMA. 1962;180(12):1038-1047. doi:10.1001/jama.1962.03050250044011

Tissue and Cellular Changes Associated with Antibody Formation in the Rat Spleen  Carl H. Gunderson, M.D., Danute Juras, Mariano F. La Via, M.D., and Robert W. Wissler, M.D., ChicagoIN 1915 HEKTOEN cited evidence demonstrating the importance of the spleen in the production of immune bodies and later showed that either the removal of the spleen or whole-body irradiation depressed production of antibodies in the rat and the dog.1-4 The importance of the spleen in antibody formation in the rat has been confirmed by recent work reported from this laboratory.5, 6In 1939 Rich, Lewis, and Wintrobe studied the cellular characteristics of the swollen spleens which follow acute infections and which are referred to as acute splenic tumors.7 They called attention to the lymphocytic characteristics of these cells. More recently, evidence has accumulated implicating the immature plasma cell in the formation of antibodies in the spleen,8