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June 23, 1962

Primary Aldosteronism: Preoperative Preparation with Spironolactone

Author Affiliations

Morrilton, Ark.; Little Rock, Ark.

JAMA. 1962;180(12):1056-1058. doi:10.1001/jama.1962.03050250062019

SINCE CONN'S ORIGINAL DESCRIPTION of the disease in 1954, the clinical manifestations of primary aldosteronism have been well-defined, and the surgical correction of this entity has become established. No further discussion of the clinical picture or the basic principles of surgical correction seem necessary at this time. However, refinements in technique of diagnosis and treatment of the disease are always important. It is with this in mind that the following case report is presented, the most important aspect being the preoperative preparation of the patient with spironolactone (Aldactone).

Report of a Case

A 53-year-old housewife was admitted to Saint Anthony Hospital in Morrilton, Ark., on July 13, 1960, with a chief complaint of "high blood pressure." The patient had been followed by one of us (JEM) since 1957, for arterial hypertension. She had been treated with rauwolfia serpentina alone and in combination with hydralazine hydrochloride; and, after having failed to