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I have no strong objections to increasing the dose of procaine penicillin G so long as the entire treatment is given in one visit. The volume of the injection becomes a problem as the dose is raised. A dose of 3,000,000 units of the drug requires the injection of 10 ml. by volume, which would best be
Schwimmer B. Antibiotic-Resistant Gonococci-Reply. JAMA. 1962;180(12):1074. doi:10.1001/jama.1962.03050250080024
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