IN THE PAST 10 years there has been no report in the English literature of a leukemoid reaction due to renal cancer. Textbooks of medicine list the signs and symptoms of renal malignancy as flank mass, flank pain, and hematuria. However, according to the Squier Urological Clinic of the Presbyterian Hospital in New York City, approximately 32% of tumors do not present with these findings. Hypercalcemia, weight loss, weakness, anorexia, metastatic lesions, hypertension, and varicocele may be the presenting manifestations of the malignancy. In addition to these findings, a review of 273 cases from the Mt. Sinai Hospital in New York City shows 15% of their cases presenting with fever only. This was low grade or as high as 105° F (40.56° C). In some cases the fever lasted between 2 and 6 months. Almost 3% had amyloid disease. The amyloid was either restricted to the involved kidney or distributed
Reiss O. Leukemoid Reaction Due to Hypernephroma. JAMA. 1962;180(13):1126–1127. doi:10.1001/jama.1962.03050260048012
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