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June 30, 1962

Secondary Breast Cancer of Prostatic Origin

Author Affiliations

University of Nebraska College of Medicine, 42nd and Dewey Ave., Omaha

JAMA. 1962;180(13):1143. doi:10.1001/jama.1962.03050260065015

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To the Editor:—  The article by J. H. Campbell et al., "Secondary Breast Cancer of Prostatic Origin" in The Journal (179:458 [Feb. 10] 1962) is misleading since its conclusions are based upon erroneous premises. Quoting their conclusions: "The masses from the breasts were proved by positive acid-phosphatase stains and quantitative acid-glycerophosphate determinations to be metastatic carcinoma of prostatic origin."The pathologic illustrations show different histologic patterns in the initial undifferentiated prostatic carcinoma (Fig. 1), and the bilateral breast carcinoma as it appeared after 7 years and 9,500 mg. of stilbestrol treatment (Fig. 3). The latter resembles duct-cell type of adenoca consistent with primary breast carcinoma.The authors should be aware that primary breast carcinomas, like most human adenocarcinoma except prostate, show strikingly elevated tissue acid-glycerophosphatase activity compared to isologous normal epithelium. This has been shown histochemically with the Gomori method, and by quantitative analysis of release of phosphate from

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