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June 20, 2012

Treatment of Refractory Mesial Temporal Lobe Epilepsy

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Servicio de Neurologia, Hospital Universitario Xeral-Cíes, Vigo, Spain (juan.gomez.alonso@sergas.es).

JAMA. 2012;307(23):2483-2485. doi:10.1001/jama.2012.4987

To the Editor: The efficacy of epilepsy surgery (73% seizure-free) in the best-possible surgical candidates was corroborated by Dr Engel and colleagues.1 Their trial also showed that surgery can cause irreversible deficits because a statistically reliable decline in performance on memory tests was more frequent in the surgical group (36% in delayed recall and 55% in naming) than in the medical group (0% and 7%, respectively).1 Other aspects of the trial might deserve some clarification.