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June 20, 2012

Posttraumatic Stress Disorder and Opioid Use Among US Veterans—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: San Francisco Veterans Affairs Medical Center, San Francisco, California (Drs Seal and Neylan; karen.seal@ucsf.edu); and Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota (Dr Krebs).

JAMA. 2012;307(23):2485-2486. doi:10.1001/jama.2012.6236

In Reply: Dr Hermos notes that the high proportion (41%) of Iraq and Afghanistan veterans with pain and PTSD diagnoses in Veterans Affairs health care prescribed both opioids and sedative hypnotics is similar to his finding of a strong association between benzodiazepine and concurrent prescriptions of oxycodone and acetaminophen and PTSD in prior-era veterans.1 He speculates that higher rates of adverse clinical outcomes in veterans with PTSD and pain prescribed opioids may be driven by the concurrent prescription of benzodiazepines.