In Reply: Dr Hermos notes that the high proportion (41%) of Iraq and Afghanistan veterans with pain and PTSD diagnoses in Veterans Affairs health care prescribed both opioids and sedative hypnotics is similar to his finding of a strong association between benzodiazepine and concurrent prescriptions of oxycodone and acetaminophen and PTSD in prior-era veterans.1 He speculates that higher rates of adverse clinical outcomes in veterans with PTSD and pain prescribed opioids may be driven by the concurrent prescription of benzodiazepines.
Seal K, Krebs E, Neylan T. Posttraumatic Stress Disorder and Opioid Use Among US Veterans—Reply. JAMA. 2012;307(23):2485–2486. doi:10.1001/jama.2012.6236
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