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Book and Media Reviews
July 25, 2012

HIV: From Biology to Prevention and Treatment

Author Affiliations

Book and Media Reviews Section Editor: John L. Zeller, MD, PhD, Contributing Editor.

Author Affiliation: Department of Infectious Disease, Oakwood Health System, Dearborn, Michigan (nghazi@umich.edu).

JAMA. 2012;308(4):410. doi:10.1001/jama.308.4.410-a

HIV: From Biology to Prevention and Treatment is more than just a primer on human immunodeficiency virus (HIV). As might be expected, the text covers HIV epidemiology and pathogenesis but also delves into the complexities of HIV replication as well as immunology and vaccine development, although the focus on currently available treatments is somewhat limited.

The book's introduction takes a broad view, looking at the origins of HIV and its similarity to other simian immunodeficiency viruses, complete with phylogenetic trees demonstrating these complex relationships. The first section of the book, “HIV Replication,” contains individual chapters on each stage in the process. These chapters are dense, although a few of the authors attempt to include some clinically relevant material; for example, the chapter on reverse transcription includes some discussion of nucleoside reverse transcriptase inhibitors and nonnucleoside reverse transcriptase inhibitors.