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February 1, 2012

Prostate Cancer Risk and Vitamin E

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Medicine, St Luke’s-Roosevelt Hospital Center, New York, New York (sh2903@columbia.edu).

JAMA. 2012;307(5):453-454. doi:10.1001/jama.2012.55

To the Editor: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed a significantly increased risk of prostate cancer in healthy men taking 400 IU/d of vitamin E compared with placebo.1 The investigators found that prostate cancer detection increased even after stopping vitamin supplementation. This finding is bound to create considerable anxiety in patients who are currently taking vitamins.