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Lab Reports
August 1, 2012

Vaccine for Smokers?

JAMA. 2012;308(5):444. doi:10.1001/jama.2012.9054

Vaccination with an adeno-associated virus gene transfer vector containing the sequence of an antinicotine antibody prevents nicotine from entering the brain and has potential as a treatment for nicotine addiction, report investigators at Weill Cornell Medical College, in New York City (Hick MJ et al. Sci Transl Med. 2012;4[140]:140ra87).

In nicotine-dependent mice treated with the vector, called AAVantiNic, blood concentrations of the anti-nicotine antibody were dose-dependent, and the antibody showed high specificity and affinity for nicotine. Also, a single dose of the therapy generated a high antibody titer at 4 weeks, which remained high at 18 weeks.