How do primary care physicians know when their patients with depression are in remission? One option is to evaluate remission by omission. Theoretically, patients who do not have depression symptoms as listed in the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) are not depressed. But recent studies indicate that the lack of symptoms alone is not an adequate gauge of remission. Busy primary care physicians need more effective, practical tools to tell them not only how their patients do not feel, but how they do feel.