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September 5, 2012

Glucose-Insulin-Potassium for Suspected Acute Myocardial Infarction

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Division of Endocrinology, Diabetes and Metabolism, State University of New York, Buffalo (Drs Chaudhuri and Dandona) (pdandona@kaleidahealth.org); and Lahey Clinic Medical Center, Burlington, Massachusetts (Dr Nesto).

JAMA. 2012;308(9):859-860. doi:10.1001/jama.2012.9768

To the Editor: Dr Selker and colleagues demonstrated that out-of-hospital administration of an infusion of glucose-insulin-potassium (GIK) in patients with suspected acute myocardial infarction (AMI) reduced the incidence of cardiac arrest or in-hospital mortality as well as infarct size.1 These outcomes occurred despite the induction of hyperglycemia (blood glucose level >160 mg/dL in 71% of the GIK group and in 45% of the placebo group), which is known to be associated with greater mortality,2 suggesting that insulin may have a cardioprotective effect.