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October 10, 2012

Postherpetic Neuralgia After Herpes Zoster Vaccination

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia (sblambert@uq.edu.au).

JAMA. 2012;308(14):1427-1428. doi:10.1001/jama.2012.12736

To the Editor: Dr Zhang and colleagues1 showed, in a cohort of older patients with specific immune-mediated diseases, a lower incidence of herpes zoster in those who had been vaccinated with herpes zoster vaccine compared with those who had not been vaccinated.

The original report2 of the efficacy study conducted in immunocompetent participants found that the herpes zoster vaccine reduced the incidence of postherpetic neuralgia by 66.5%. Given that postherpetic neuralgia following herpes zoster is more common in immunosuppressed patients,3 and that there are limited effectiveness data for postherpetic neuralgia following herpes zoster vaccine generally, were the authors able to examine postherpetic neuralgia in their study?

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