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Article
November 24, 1962

Regional Notes

JAMA. 1962;182(8):39-40. doi:10.1001/jama.1962.03050470077033

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Abstract

Report Progress in Blocking Drug-Resistant Bacteria  Researchers in the department of microbiology at the University of Pennsylvania have reported a method found successful in the case of three species of bacteria in preventing the emergence of drug-resistant bacterial mutants.The report was made Nov. 1 by Dr. M. G. Sevag, associate professor of microbiology, who spoke in Chicago at the second Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology. His paper, co-authored by his associate, Dr. William T. Drabble, was titled "Prevention of the Development of Microbial Resistance to Drugs."Sevag's report described the action of spermine when used with an antibiotic against a culture of bacteria. Spermine (as well as spermidine, a smaller molecule derived from spermine, and found to behave identically in these studies) is a basic substance found in semen, mammalian tissue, microorganisms, sputum, the secretion of certain spiders, and other

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