A study was undertaken to determine whether or not repeated applications of cigarette smoke condensate to the bronchial mucosa would be capable of producing progressive proliferative changes, including carcinoma in situ and invasive carcinoma. One-fourth of 1 cc. of cigarette smoke condensate was applied to the mesial wall of the left primary bronchus of 130 dogs, 3 to 5 times weekly. In 25 dogs the same area was submitted to rubbing manipulations. The bronchial mucosa of 27 nontreated dogs was also examined. The changes were followed up by repeated mucosal biopsies and by autopsies. Papilloma was produced in 2, precancerous changes in 25, carcinoma in situ in 3, and invasive carcinoma in 1 of of the 130 dogs treated with cigarette smoke condensate.
Rockey EE, Speer FD, Thompson SA, Ahn KJ, Hirose T. Experimental Study on Effect of Cigarette Smoke Condensate on Bronchial Mucosa. JAMA. 1962;182(11):1094–1098. doi:10.1001/jama.1962.03050500026007
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