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December 15, 1962

Anticoagulant therapy

JAMA. 1962;182(11):1138. doi:10.1001/jama.1962.03050500070024

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This very carefully written book on anticoagulants should prove to be a most valuable reference work. Two chapters are devoted to the history of the discovery and development of heparin, and bishydroxycoumarin ( Dicumarol) and its allies, and another to a short discussion of other anticoagulants. There are then chapters on the coagulation mechanism, the mechanism of thrombus production, and fibrinolysis. The action of the anticoagulant drugs is thoroughly explained, their chemistry and pharmacology are presented in great detail, and laboratory tests for their control are carefully described. An extensive list of references appears at the end of each chapter.

The author, who is a physician, goes into the clinical use of these drugs in some detail. It is rather surprising to find that he offers very few uses for heparin, mentioning mainly its use in vascular and cardiac surgery and in instances of acute peripheral artery obstruction. Only parenthetically, in