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Article
December 29, 1962

A FUNNY THING HAPPENED ON THE WAY TO GET SOME YOGHURT

JAMA. 1962;182(13):1329-1330. doi:10.1001/jama.1962.03050520027010
Abstract

Man's preoccupation with his gut is probably as old as himself. What he puts into it and what is moved out of it have long been matters of more than passing interest. More often than we would care to guess, the state of a nation has depended on the state of a gut.

Although this intense awareness has shown no signs of being on the wane, in recent times it has become more sophisticated to be less concerned about the transient solids and more concerned about the resident population of the lower gut. Indeed, this concern may well be legitimate. Some of the traits that we have always attributed to grandpa's genes may well be due to our fecal flora.

For the past 4 years Dubos and Schaedler1 of the Rockefeller Institute have been comparing two colonies of mice which have markedly different intestinal flora. The original colony, SS,

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