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Book and Media Reviews
November 14, 2012

The Biology of Alzheimer Disease

JAMA. 2012;308(18):1925-1926. doi:10.1001/jama.308.18.1925

The study of Alzheimer disease has undergone rapid change in recent years. Research has revealed exciting advances in the understanding of the biology of the disease and its clinical course. The recent revision of Alzheimer diagnostic criteria represents an important milestone resulting from the integration of decades of work conducted among animals and humans on the biological markers of disease. However, these developments have also been accompanied by frustrating challenges in drug trials and prevention, because there still is no successful preventive or disease-modifying treatment. The fast-paced nature of Alzheimer research thus generates a moving target for researchers, medical professionals, and the interested public who seek to stay up to date with the field.